Pages

Showing posts with label Dreams. Show all posts
Showing posts with label Dreams. Show all posts

Monday, 6 October 2014

55 applications later...

After countless alterations to my CV and a shameless outpouring of enthusiasm into numerous cover letters, I am finally about to start the next step of my career.

In my search for the perfect career move I sent out 55 applications in total. Many of these were actually for industry positions that I thought, "well I can do that, it would be ok and is kind of my skill set", and so I was not too surprised when I didn't get the job. But I was always optimistic and therefore always disappointed. I really wanted that perfect research position of five years to really develop a new idea that I was totally specialised for. But yeah, that doesn't actually happen.

In the meantime I began volunteering at a University. They were more than happy to have me work for free, which was very kind of them. In this time I did manage to get a couple small grants to help with the work and also to send me to talk at a conference. I did gain some great experience and some very helpful contacts. However, I learnt during this time that not having a stable, secure job is not something I would particularly recommend.

Out of all my 55 applications, I was invited six times for interviews. Three of which, much like the proverbial buses, came along at the same time. In the end I was in the most fortunate position of having a choice of where to go next and actually went to my final interview with an offer already in my pocket. I had been offered a position in industry (still in R&D), which was with a very exciting company and perfect for my expertise. My final interview was at a University and for a one year postdoc position. The research ideas were fantastic, the facilities amazing but the prospects and possibilities for the future were just that, prospects and possibilities.

After moving country a year ago and previously moving nine times in my eight years at University, I was ready to stay put for a change. I would love to continue research in a University atmosphere but not in the way that the traditional career path dictates or how the funding situation obliges people to continually move on after short projects. Therefore I said thank you very much, but no thank you to the academic path and willingly moved into industry.

I had already thought for a while that the long term academic plan was not what I wanted. I love research, I love exploring new ideas, discovering new things. But there are other options than the academic track. I like writing (obviously) and so publishing, editing and science communication is still something for future Tom to consider. But right now I still want to be part the doing science community not just the reporting about it part. So industry it is.

My final thoughts on the matter are on the similar difficulties facing other freshly graduated PhDs. In Holland, where I'm based, the funding situation in universities is not in good shape and industries are not doing much better either. I do feel that if I was able (and willing) to travel anywhere in the world, then I would have been much more likely to land something close to my dream job much more quickly. But the restrictions that come with staying put make things more difficult.

If you (like me) are intent on not moving then you better keep writing those applications and in the meantime improvise with what you do have, volunteer and ask for help. This last point being the most important. I wouldn't have got this far without a lot of support from friends and old colleagues.

Sunday, 25 August 2013

Dalí makes it into Nature Chemical Biology

Wow, just wow. Nature Chemical Biology has done it. Yes they have published the most bizarre and surreal image ever to be unleashed on a journal front cover.

Dali Nature Chemical Biology
Dream caused by neuronal decay

Salvador Dalí could never have imagined that one day his work would feature in such a prominent place for an artist of his stature. He could not have thought this in his wildest dreams, and he did have some pretty wild dreams. The image takes inspiration from 3 of his famous paintings, the first being "Dream caused by the flight of a bee around a pomegranate a second before awakening". Well, there are no pomegranates here but we do have a tiger leaping out of the sky and clamping its jaw around a neuron. Pretty cool and not quite as confusing as the pomegranate, fish, tiger, tiger, gun sequence from the original painting. The melting clock in the foreground is of course from Dalí's "The persistence of memory", its presence here probably a sad reflection that Huntington's disease can affect many people early in their lives. And finally the trees in the background come from "The three sphinxes of bikini". They are meant to symbolise the mushroom cloud of an atomic bomb in the original painting and so here gives another hint to the deadly nature of the disease. Not really much fun here after all.

I like that Nature Chem Bio does give you a little peak into what the authors were smoking when they made the image. The tiger apparently is meant to show the "difference in proteostasis mechanisms" which determines the "longevity of a neuron". Hence why our tiger is trying to eat that giant neuron.

No tigers were harmed during the making of this cover

The Paper: Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration
Found at: Nature Chemical Biology, 2013, 9, 586-592

The paper is a study on the huntingtin toxin, a protein that causes Huntington's disease. The level of glutamine residues in the toxin can vary and it is this variation that leads to the protein misfolding and causing the disease. The larger polyglutamine regions were important as they also reduced the lifetime of the toxin. It was found that different neurons cleared the huntingtin toxin at different rates, with cortical neurons acting quicker than striatal neurons and thus living longer. They concluded that the biological pathways and in particular the Nrf2 pathway, responsible for protein degradation would be good targets for therapeutics for treating misfolded protein diseases. So maybe some good news in the end.